Typbar TCV®

Typbar TCV® is a vaccine containing polysaccharide of Salmonella typhi Ty2 conjugated to Tetanus Toxoid. Vi Capsular polysaccharide of Salmonella typhi alone elicits B cell responses. Still, the conjugation of bacterial polysaccharide to a protein carrier provides foreign peptide antigens presented to the immune system, eliciting antigen-specific CD4+ Th cells, referred to as T-dependent antibody responses. A hallmark of T-dependent reactions, also evoked by toxoids, is to induce higher-affinity antibodies and long-term immune memory.

Typbar TCV® is the world’s first clinically proven conjugate Typhoid vaccine. Further, Typbar TCV® is the only approved vaccine for children and infants less than 2 years of age. During the phase 3clinical study, a single dose of Typbar TCV® elicited 4-fold seroconversion rates of 98.05%, 99.17% and 92.13% in subjects between ≥6 months to 2 years, ˃2 to 15 years and ˃15 to 45 years, respectively. The results of this study were published in the Journal of Clinical Infectious Diseases.

A human challenge study at the University of Oxford demonstrated that the vaccine is safe, 100% immunogenic, and prevents up to 87.1% of infections when using real-life definitions of typhoid fever. Typbar TCV® has been recommended by the experts at the WHO-Strategic Advisory Group for routine immunizations and is WHO-prequalified.